Penzance is well connected to the rest of the County of Cornwall and to all parts of the mainland by road and rail.

The town is the terminus of the main-line rail service with frequent services to and from London and the South-East and to the Midlands, Wales, the North of England and to Scotland. It is also connected by express coach services using the A30 trunk road, largely on dual-carriageway, to Plymouth, Exeter, Bristol, London and the North via the Motorway network. Ferry services by air and sea operate between the town and the Isles of Scilly.

Local bus services are centred on Penzance with frequent services on routes to all outlying areas, while taxis are available from Penzance station or on call.

Car rental and cycle hire allow for independent touring in the area and boat trips, for sightseeing or fishing, operate from Penzance Harbour.